A new comprehensive review in Nutrients argues that vitamin D supplements reduce cardiovascular disease (CVD) risk, challenging previous randomized controlled trials (RCTs) that showed no effect.
Lead author William B. Grant, PhD, noted that RCTs, designed primarily for drugs with narrow dose-response curves, may not fully capture the benefits of nutrients like vitamin D, which have broader, threshold-based effects. The team reviewed over 40 years of observational and ecological studies linking vitamin D to significant improvements in CVD mortality.
Vitamin D’s cardiovascular benefits include lowering blood pressure and reducing inflammation. The authors recommend vitamin D as part of an integrated strategy alongside other supplements, a heart-healthy diet, and medications to manage and prevent CVD.
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